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Classical Hodgkin Lymphoma

Name of disease:

Classical Hodgkin Lymphoma

ICD-10 diagnosis code:



Classical Hodgkin Lymphoma develops when B-lymphocytes undergoes genetic mutations that leads to rapid cell multiplication. It is associated with exposure to EBV or HIV.

Pattern of inheritance:

De novo mutation


Classical Hodgkin lymphoma accounts for 10-15% of all types of lymphomas and 90-95% of all Hodgkin lymphomas. The incidence ranges from 2-3 cases per 100,000 people in developed countries.


Physical examinations assess the signs and symptoms. Biopsy of involved tissue removed from the swollen lymph nodes to confirm diagnosis.

Age of onset:

Commonly diagnosed at age between 15-40 and age above 60. Diagnosis in children under the age of 10 is rare.

Common signs and symptoms:

Painless swollen neck, armpit or groin Abnormal fatique Abnormal weight loss Itching Unexplained cough Fever Shortness of breath

Available treatments (medicinal and non-medicinal):

Different types of radiotherapeutic and immunotherapeutic (e.g. ABVD) are used depend on the stage of tumor progression. Stem cell transplant are used occasionally.

Disease management tips:

Periodic general check-ups are recommended to track tumor development. Follow-ups are needed for possible late effects of treatment such as secondary malignancy and cardioc toxicity.


Other useful websites:

More about the disease: Lymphoma Action | Classical Hodgkin lymphoma(UK)http://lymphoma-action.org.uk/ Cancer Therapy Advisorhttps://www.cancertherapyadvisor.com/home/decision-support-in-medicine/labmed/classical-hodgkin-lymphoma-chl/